falciparum strain — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2027	Oxysanguinarine	8-Oxosanguinarine,Hydroxysanguinarine	Parasite
	Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.		Parasite
TCS2070	Homogentisic acid	2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid	Antioxidant , Endogenous Metabolite
	1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidant...		Antioxidant , Endogenous Metabolite
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T12084	MMV008138		Others
	MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM).		Others
TN4717	Oplopanone		Antifection
	Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain.		Antifection
TN3583	Canophyllal		Antifection
	Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.		Antifection
T70034	Dehatrine
	Dehatrine is from an Indonesian medical plant Beilschmiedia madang; a bisbibenzylisoquinoline alkaloid; inhibits growth of cultured Plasmodium falciparum K1 strain.
T62600	RYL-552S
	RYL-552S is a drug-resistant strain of Plasmodium falciparum that effectively kills the asexual blood stage of the parasite in vitro.
T72396	Antimalarial agent 20
	Antimalarial agent 20, exhibiting potent efficacy with an IC50 value of 0.6 nM against the P. falciparum NF54 parasite strain within the NF54 albumax assay, serves as a significant antimalarial compound.
T75568	Z-Antiepilepsirine
	Z-Antiepilepsirine, an amide alkaloid present in Piper capense L.f., exhibits antiplasmodial properties, demonstrating an IC50 value of 27 µM against the W2 strain of Plasmodium falciparum [1].
T35485	6-Prenylindole
	6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (1...
T78951	Antimalarial agent 24		Parasite
	Compound 24 (Compound 7), an in vitro antimalarial agent, demonstrates inhibitory activity against the Plasmodium falciparum W2 strain with an IC50 of 0.81 μM and exhibits a cytotoxicity threshold (CC50) exceeding 200 μM...		Parasite
TN4113	Garcinone E		Antifection
	Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent...		Antifection
T116970	TLC3407-3786
	MMV665916 is a quinazolinedione derivative that is an antimalarial agent. MMV665916 shows remarkable antiplasmodial activity against P. falciparum FcB1 strain with EC 50 value of 0.4 μM and presents the high selectivity ...
TN4449	Longistylin C		Antifection
	Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vit...		Antifection
T35758	Butyrolactone V
	Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amaz...
T83044	Antimalarial agent 33		Parasite
	Antimalarial agent 33 (compound 5g) exhibits antiplasmodial activity targeting both erythrocytic and hepatic stages of Plasmodium, with an effective concentration (EC50) of 1.1 μM against the K1 strain of P. falciparum. ...		Parasite
T78184	MMV009085
	MMV009085 is a potent inhibitor of the Plasmodium falciparum hexose transporter (Pf HT1), with potential as an anti-malarial agent. It also inhibits the human glucose transporter, demonstrating high potency with an IC50 ...
T79632	Antileishmanial agent-21		Parasite
	Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin....		Parasite
T83899	N-didesmethyl Loperamide	R 21345
	N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the s...